We used a proteomics based approach and identified the cell-adhesion molecule nerve injury-induced protein 1 (Ninjurin1), described as two-pass transmembrane cell-surface protein [7], to be increased in the myocardium of patients with severe aortic stenosis, suggesting a role of Ninjurin1 in pathological cardiac hypertrophy. This evidence concerns the gene NINJ1 and aortic stenosis.