Here, we genotyped a set of potentially functional SNPs in the MUC1, MUC2, MUC4, MUC5AC, MUC6, and B3GNT6 genes in a case-control study of 1532 CRC patients and 1108 healthy controls from the Czech Republic and evaluated their association with CRC susceptibility, progression, and prognosis. Here, MUC5AC is linked to colorectal carcinoma.