B3GNT6 and colorectal cancer: In addition to mucins, also the core 3 synthase, acetylgalactosaminyl-O-glycosyl-glycoprotein beta-1,3-N-acetylglucosaminyltransferase, encoded by the B3GNT6 gene in humans, has been reported to be significantly down-regulated in colorectal cancer samples [24].