POMC and Cushing syndrome due to macronodular adrenal hyperplasia: 11 In our patients, the 3T MRI’s detection of the adenoma allowed for surgeryto be suggested, even for the patient in which the BIPSS presented indeterminateresults. Thus, the patients were cured. Currently, it is established that inpatients with ACTH-dependent Cushing’s syndrome, the presence of a pituitary adenomawith a diameter between 6 mm3 and 10 mm3 (macroadenoma) ishighly suggestive of Cushing’s Disease, 4 making additional exams like BIPSS unnecessary.