KMT2A and cancer: The KMTs family contains the SET domain that methylates H3K4 and can promote genome accessibility and transcription.3 There are three pairs of KMTs members: KMT2A/KMT2D, KMT2C/KMT2B, SETd1A/SETd1B, which all play important roles in cacinogenesis, cancer progression and prognosis.