Analysis of patient samples has revealed a correlation between high CTSZ expression levels and advanced malignancy.8, 9 In addition, CTSZ has been indicated to affect the epithelial‐to‐mesenchymal transition (EMT) and promote cancer invasion and metastasis.10 However, there is no report on the role of CTSZ in CRC development. This evidence concerns the gene CTSZ and cancer.