CTSZ and colorectal carcinoma: Analysis of patient samples has revealed a correlation between high CTSZ expression levels and advanced malignancy.8, 9 In addition, CTSZ has been indicated to affect the epithelial‐to‐mesenchymal transition (EMT) and promote cancer invasion and metastasis.10 However, there is no report on the role of CTSZ in CRC development.