TWIST1 not only involves in embryonic organogenesis, specification, and differentiation, but also is associated with tumor initiation, angiogenesis, stemness and EMT (epithelial‐mesenchymal transition) promotion, leading tumor cell invasion and metastasis in a variety of human malignancies (Forghanifard, Rad, et al., 2017). The gene discussed is TWIST1; the disease is neoplasm.