MEIS1 and nonpapillary renal cell carcinoma: On the other hand, several studies have demonstrated that MEIS1 acts as potential tumor suppressor in some tumors such as ccRCC, prostate, lung, gastric, and colorectal cancers through promoting cell differentiation and inhibition of epithelial cell proliferation (Chen et al., 2012; Song, Wang, & Wang, 2017; Zhu et al., 2017).