ERG and neoplasm: There also appears to be racial discordance in the mechanism of TMPRSS2‐ERG occurrence, with African Americans most commonly exhibiting fusion through deletion, and European and Asian Americans through translocation.4 Intriguingly, African ancestry is significantly associated with high‐grade (Gleason score ≥ 8) PCa,5 which questions the role of TMPRSS2‐ERG fusions in tumor development in African populations.