TMPRSS2 and posterior cortical atrophy: This genomic alteration appears to occur early in tumourigenesis, resulting in fusion of the androgen‐regulated transmembrane protease serine 2 gene (TMPRSS2) to a member of the transcription factor erythroblastosis virus E26 transforming sequence family (ERG)1, leading to androgen‐dependent overexpression of ERG.2 The frequency of TMPRSS2‐ERG fusions in PCa shows a notable racial disparity.