The PD-L1(+) CTC detection rate in previously treated NSCLC at the baseline appears to be similar between the two studies but significantly higher than that in naïve untreated patients assessed by us and Boffa et al. It is noteworthy to mention that our platform demonstrated a much higher PD-L1(+) CTC detection rate than the CTC detection method used by Boffa et al. This discrepancy could be due to lower sensitivity of the technology utilized by Boffa et al. [13]. The gene discussed is CD274; the disease is non-small cell lung carcinoma.