Kamstrup and Nordestgaard suggested that the large Lp(a) isoform size, which is exhibited in subjects with low Lp(a) levels, may elevate the activity of lipoprotein-associated phospholipase A2 (Lp-PLA2) [20], which stimulates the production of inflammatory cytokines in adipose tissue and leads to insulin resistance [31]. The gene discussed is LPA; the disease is Insulin resistance.