KCNA5 and myocardial ischemia: Indeed, the absence of Kv1.5 in mice facilitates myocardial ischemia, but it is not lethal, coronary dilatation in response to H2O2 is not completely abolished in Kv1.5−/− mice, and moreover in Kv1.5−/− mice there is an upregulation of Kir6.2, Kir6.1, and Kv1.2, suggesting a compensative role of these channels for coronary blood flow regulation in the absence of Kv1.5 [100].