The main organ concerned with energy homeostasis is the liver, It is also an important target for CLA effects that differ according to the type of isomer; e.g., in animals, trans-10,cis-12 caused increased lipid accumulation and hepatic steatosis but neither trans-10,cis-12 nor cis-9,trans-11 CLA has an effect on atherosclerosis [25]; both isomers promote insulin sensitivity by reducing adipose inflammation [26], and both also protect against oxidative stress and enhance hepatic mitochondrial function decreasing insulin resistance in rats by both isomers [27]. This evidence concerns the gene INS and fatty liver disease.