It mainly enhances hepatic mitochondrial function and conveys protection against oxidative stress through action on mitochondrial antioxidant enzymes increasing their activities while of the different CLA isomers, trans-10,cis-12 CLA (which is taken in supplement) causes increased lipid accumulation mainly through reduction of adiponectin and leptin leading to hepatic steatosis [42]. This evidence concerns the gene LEP and fatty liver disease.