We decided for a watchful waiting approach and the patient remained clinically and biochemically stable over a 24-month followup.<h4>Conclusion</h4><i>CYP24A1</i> gene mutations should be considered in cases of PTH-independent hypercalcemia, once that more common causes (hypercalcemia of malignancy, granulomatous diseases, and vitamin D intoxication) have been ruled out. Here, PTH is linked to hypercalcemia disease.