Endocan retained its prognostic value also after adjusting for established HF parameters (namely, age, gender, ischemic HF etiology, NYHA classification, LVEF, NT-proBNP, and 6MWT) in a multivariate analysis (HR, 1.471 CI 95% 1.183-1.829, p = 0.001) (Table 3). This evidence concerns the gene NPPB and hydrops fetalis.