In the 108 cases of CRC whose stages were identified based on the surgically resected specimens, methylated SEPT9 alone was positive in 38.5% of stage I (5/13), 81.6% of stage II (40/49), 69.2% of stage III (27/39), and 100% of stage IV (7/7). This evidence concerns the gene SEPTIN9 and colorectal carcinoma.