TWIST1 and breast cancer: Several publications investigated the mechanism underlying the antiproliferative effect of quercetin as it plays a crucial role in limiting the cancerous cell proliferation as was reported to induce cell cycle arrest during either G1 or G2/M and decreasing expression of Bax gene, reduced apoptotic index, increased cell viability and antiproliferative effect on MCF-7 cells (26), besides the apoptotic activity in different breast cancer cells through suppression of Twist via p38MAPK pathway (27).