Our data is also in agreement with published work, which indicates an increase in caspase-3 activity by F1 fraction ref. In another study ona marine mollusk, bioactive compounds isolated from the egg mass extract of Dicathaisorbita, induced an apoptotic effect by increasing caspase 3/7 activity, and arresting the G2/M phase of the cell cycle in the colorectal cancer cell lines (37). This evidence concerns the gene CASP3 and colorectal cancer.