Previously, we and others demonstrated that inactivation of the APC/C is more effective when multiple protein interactions are simultaneously disrupted using proTAME and apcin.15,36 ProTAME blocks the interaction between the APC/C and its co-activators, while apcin inhibits the interaction between the co-activators and their substrates.36 This combination resulted in a synergistic anti-lymphoma effect in all cell lines. This evidence concerns the gene APC and lymphoma.