Changes in the expression/activation of one or both of these co-activators subsequently result in alterations in the APC/C activity.39 Thus, to investigate the involvement of the APC/C in DLBCL and MCL disease, we investigated the expression of APC/C co-activators Cdc20 and Cdh1 using publicly available gene expression profiling data from DLBCL and MCL patients. The gene discussed is APC; the disease is diffuse large B-cell lymphoma.