E2F8 and lung cancer: In addition, E2F8 target genes which include CDC6, SASS6 and E2F8 itself, were significantly enriched among differentially expressed genes following HKlincR1 knockdown (Gene Set Enrichment NES Score = −1.41; p-value < 0.005) in an independent E2F8 ChIP-Seq dataset from lung cancer cell lines52 (Supplementary Fig. S4B).