In vivo and in vitro studies of tumour models have demonstrated that increased expression of CADM2 mRNA or protein is associated with reduced cell viability, proliferation, migration and invasion in glioma53, retinoblastoma54, renal cell55, hepatocellular56,57, endometrial58, prostate59 and oesophageal squamous cell carcinomas60. Here, CADM2 is linked to neoplasm.