IFNA1 and asthma: IFN signaling, including type I and III IFNs that can be produced by airway epithelial cells54,55, is known to regulate innate and adaptive type I and II immune responses (dendritic cells/Th1/Th2/Treg) following viral/bacterial/allergen challenges85–88 and contribute to asthma development/exacerbation89,90.