Accordingly, there was increased expression of Muc5ac, pro-Th2 and Th17 cytokine (e.g., Il13, Il33 and Il17a), increased BALF eosinophilia, as well as increased genes involved in epithelial repair responses in the lungs (e.g. Egfr and Tff2). The gene discussed is MUC5AC; the disease is Increased total eosinophil count.