In the first cluster, 100% of pairs of cancer biomarkers (36/36) exhibited positive correlation (adjusted P < 0.05) with the highest correlations between FGF2 and leptin (ρ = 0.84, P < 0.0001), FGF2 and TRAIL (ρ = 0.80, P < 0.0001) and leptin and TRAIL (ρ = 0.77, P < 0.0001). The gene discussed is LEP; the disease is cancer.