Interestingly, a subset of identified cancer biomarkers (TNFα, sFasL, TRAIL, prolactin, FGF2, SCF, OPN), which were identified in the high diversity/inflammation cluster, were also correlated with Lactobacillus abundance, vaginal pH and genital inflammation (Fig. 3B) and were elevated in the ICC group (Fig. 1A). This evidence concerns the gene TNF and intrahepatic cholangiocarcinoma.