First, we observed epithelial hyperplasia with squamous metaplasia had positive expression of p63 and CK5 in Lkb1d/d (Supplementary Fig. 1e) and in Lkb1d/dJnk1d/dJnk2−/− (Fig. 4b) mice, but both epithelial hyperplasia and adenomas had negative expression of p63 and CK5 in KrasG12D mice (Supplementary Fig. 2f). This evidence concerns the gene KRT5 and adenoma.