Instead, lungs of Pten deletion, P53 ablation, Errfi1 knockout or KrasG12D activation had AD tumors, adenomas and atypical adenomatous hyperplasia that showed opposite profiles of marker expression compared with lung SCCs in Lkb1d/d mice (Table 1 and Supplementary Fig. 2b−f)8,29. The gene discussed is PTEN; the disease is Alzheimer disease.