Compared to 11−14-month-old Lkb1d/d mice that showed epithelial hyperplasia (5.4%) (Supplementary Fig. 1c–d), epithelial hyperplasia with squamous metaplasia (1.8%) (Supplementary Fig. 1e), squamous metaplasia (1.8%), adenocarcinoma with squamous differentiation (10.7%) (Supplementary Fig. 1f), ASC (5.4%) (Supplementary Fig. 1g), SCC (16.1%) (Fig. 1a, b) (Supplementary Data 1−2), and loss of Jnk1/2 in the Lkb1-deficient background accelerated LSCC development in vivo. The gene discussed is MAPK8; the disease is adenocarcinoma.