Meanwhile, progressive lung SCC developmental stages (SCC-DSs) were also observed after Lkb1 ablation (Supplementary Data 1-2), including epithelial hyperplasia (5.4%) (Supplementary Fig. 1e), squamous metaplasia (1.8%) (Supplementary Fig. 1e), adenocarcinoma with squamous differentiation (10.7%) (Supplementary Fig. 1f) and adenosquamous carcinoma (ASC) (5.4%) (Supplementary Fig. 1g). The gene discussed is STK11; the disease is adenosquamous carcinoma.