Hence, when comparing human tumor and non-tumorous liver samples overexpression of NUP155 and FTSJ1 in HCC is most likely due to a loss of p53′s wild-type function followed by a de-repression in a considerable fraction of tumors, since inactivation of p53 (either functionally or genetically) frequently occurs in human HCC43. Here, TP53 is linked to hepatocellular carcinoma.