We have previously shown that T1D-relevant antigen-specific TR1-like CD4+ T-cells selectively suppress the proinflammatory and antigen-presenting capacity of pancreatic lymph node-associated APCs by recognizing cognate pMHC class II complexes on autoantigen-loaded APCs draining the pancreas (the source of autoantigenic material)1,2. Here, CD4 is linked to type 1 diabetes mellitus.