To investigate this, we tested the ability of PDC-E2166–181/IAg7-NPs (PBC-relevant) and CYPD398–412/IAg7-NPs (AIH-relevant) to expand cognate TR1-like CD4+ T-cells and ameliorate PSC in NOD.Abcb4–/– mice. The gene discussed is ABCB4; the disease is autoimmune hepatitis.