PDC and primary biliary cholangitis: Treatment of 15-week-old NOD.c3c4 mice with PDC-E2166–181/IAg7-NPs and PDC-E282–96/IAg7-NPs, but not BDC2.5/IAg7-NPs (displaying a pancreatic beta cell-specific epitope), resulted in significant reductions in all examined biochemical, immunological, macroscopic, and microscopic readouts of PBC (Fig. 3a–f).