In other organ-specific autoimmune disorders, such as in liver autoimmune diseases—primary biliary cholangitis (PBC), primary sclerosing cholangitis (PSC) or autoimmune hepatitis (AIH)—the autoimmune response focuses on liver-enriched, non-organ-specific antigens, such as the mitochondrial pyruvate dehydrogenase complex-E2 component (PDC-E2) in PBC; or nuclear, cytoplasmic, or Golgi-enriched proteins, such as F-actin, formimidoyltransferase cyclodeaminase (FTCD), or cytochrome P450 (CYPD2D6) in AIH; or tropomyosin isoform 5 (hTM5) in PSC, among several others5–7. The gene discussed is TPM3; the disease is primary biliary cholangitis.