GPT and primary biliary cholangitis: Intake of UDCA-supplemented chow by 6-week-old NOD.c3c4 mice for 14 weeks had a small therapeutic effect on the progression of PBC, as manifested by reductions in liver scores and liver weight, bile duct proliferation and mononuclear cell infiltration, albeit not serum ALT or TBA levels, CBD scores, CBD diameter, or bile duct involvement (Fig. 7a–d).