To investigate whether this is also the case for liver autoimmune disease-relevant TR1-like CD4+ T-cells, we compared the cytokine/chemokine profiles of CD11b+ cells purified from the portal/celiac (liver-draining) and mesenteric (non-draining, control) lymph nodes (PCLN and MLN, respectively) of PDC-E2166–181/IAg7-NP-treated vs. control NP-treated animals (Supplementary Fig. 2a). This evidence concerns the gene CD4 and autoimmune disease.