We reasoned that the large bile duct and parenchymal liver damage that underlie PSC and AIH, respectively, might trigger the release of PDC-E2, CYP2D22 (the mouse CYP2D6 ortholog, herein referred to CYPD) and FTCD, and the priming of autoreactive CD4+ T-cells capable of responding to the corresponding pMHC-NPs. This evidence concerns the gene CYP2D6 and autoimmune hepatitis.