We compared the ability of PDC-E2122–135/DRB4*0101-NPs, PDC-E2249–262/DRB4*0101-NPs, and PDC-E2629–643/DRB1*0801-NPs to expand cognate TR1-like CD4+ T-cells in NOD.scid/Il2rg–/– (NSG) hosts reconstituted with PBMCs from 11 DRB4*0101+ and 5 DRB1*0801+ PBC patients (PBL-NSG mice, Supplementary Fig. 4 and Supplementary Table 1). This evidence concerns the gene HLA-DRB1 and primary biliary cholangitis.