Upregulation of XPO1 is observed in many types of cancer tissues such as lung cancer, osteosarcoma, pancreatic cancer, ovarian cancer, cervical carcinoma, gastric and hepatocellular carcinoma, myeloid and lymphoid leukemia, mantle cell lymphoma, and multiple myeloma tissues (22). This evidence concerns the gene XPO1 and hepatocellular carcinoma.