Of these 9 groups, genes in group 8 were likely essential or pro-oncogenic for KMM cells but not for MM cells; among them, 18 genes, including Naa38, Rpl9_like, Rpl23a, Spcs3, Hspa14_like, Nfyb, Eif2b2, Mrpl55, Pold1, Nup43, Lin52, Csnk1a1, Aldoa, Rpl6, Ddx6, Wdr74, Rars, and Cnot1, had CRISPR score ratios of ≤5 (−32-fold) at day 21 compared to day 1 for KMM cells. Here, RPL23A is linked to Miyoshi myopathy.