Compared to the levels in NSC-transfected cells, the HRSV N protein was also barely detectable in the absence of ABCE1, and MuV N protein expression was reduced by more than 50% (Fig. 5B), which correlated with the impact of ABCE1 knockdown on the replication efficiency of these viruses (Fig. 4B and C), suggesting that ABCE1 plays an important role in the accumulation of viral proteins during infection. This evidence concerns the gene ABCE1 and infection.