Genes (or RNAs) related to other identified CpGs have also been reported to have implications in cancers such as the long non-coding (lnc) RNA HCP5 and the gene TREM2 in gliomas [40, 41], and the genes NCOA4 and C4orf17 in prostate and ovarian cancers[42–44]. Here, HCP5 is linked to central nervous system cancer.