However, prior studies have suggested limited predictive values of the widely used biomarkers for diagnosis of PJI, including serum erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) [8, 9], synovial white blood cell (WBC) count and percentage of polymorphonuclear cells (PMN%) [7], aspiration culture [10], and histology analysis [11, 12]. This evidence concerns the gene CRP and juvenile polyposis syndrome.