In particular, few Authors focused on sarcoma: a study showed that that Kv1.3 voltage-gated potassium channels was upregulated in human osteosarcoma and downregulation of Kv1.3 suppressed osteosarcoma growth in vivo and osteosarcoma cell proliferation in vitro, accompanied by increased apoptosis [44]. The gene discussed is KCNA3; the disease is osteosarcoma.