MT-RNR2 and Q fever: Stimulation of PBMCs with LPS resulted in a decreased median production of humanin in QFS patients (371 pg/mL; IQR 325–384), CFS patients (364 pg/mL; IQR 316–387), and asymptomatic Q fever seropositive controls (354 pg/mL; 292–393), compared to healthy controls (395 pg/mL; 372–409) (P = 0.05) (Fig. 4a).