To further substantiate this finding we stimulated PBMCs of these patients with LPS for 24 h and found that this resulted in lower production of humanin, but not MOTS-c, in CFS patients, QFS patients, and asymptomatic Q fever seropositive controls, compared to healthy controls. The gene discussed is MT-RNR2; the disease is myalgic encephalomeyelitis/chronic fatigue syndrome.