To investigate whether ANXA11 mediated the biological function of miR-16-5p and AGAP2-AS1 on HCC cells, ANXA11 was respectively restored in miR-16-5p-overexpressing or AGAP2-AS1 knockdown HCCLM3 cells and inhibited by specific siRNA in miR-16-5p-suppressive or AGAP2-AS1 overexpression Hep3B cells (P < 0.05, Fig. 8a). The gene discussed is AGAP2; the disease is hepatocellular carcinoma.