Furthermore, the Kaplan-Meier survival analysis showed that HCC patients with high AGAP2-AS1 group had a poorer overall survival (OS) and disease-free survival (DFS), while miR-16-5p low-expressing patients presented a shorter OS and DFS (P < 0.05, respectively, Fig.6a-d). The gene discussed is AGAP2; the disease is hepatocellular carcinoma.