ANXA11 and hepatocellular carcinoma: To explore the mechanisms by which miR-16-5p regulates HCC cell growth and metastasis, informatics tools of three miRNA target-prediction programs (TargetScan, miRDB and PicTar) were used to search for the candidate targets and found ANXA11 3’UTR contains the binding sits of miR-16-5p conserved putative (Fig.7a).