PGR and breast cancer: As shown in Table 5, in the breast cancer patients with c-erb positive and PR positive, when the TIMP-2 rs2277698 CC genotype was used as a reference, individuals carrying the TT genotype promoted the risk of breast cancer by 72 and 63% in allele model, respectively (c-erb positive: OR = 1.72, 95%CI: 1.08–2.74, p = 0.022; PR positive: OR = 1.63, 95%CI: 1.09–2.43, p = 0.017).