In our study PCDHAC2 resulted hypomethylated, whereas PCDHGC5 was hypermethylated in all PDAC samples and the same patterns of methylation were also observed in matched adjacent non-neoplastic pancreatic tissues, suggesting that CpG promoter methylation of these genes does not play a major role in the biology of this tumor. The gene discussed is PCDHGC5; the disease is neoplasm.