TP53 and colorectal carcinoma: CIMP status in CRC has been shown to be associated with some specific clinical features (female sex, older age, family history of CRC, proximal location in the colon, mucinous cell differentiation) as well as some genetic features (sporadic MSI, wild-type TP53, mutations of BRAF and KRAS, and MLH1 promoter methylation) [37–39].The MSI is caused by a hypermutable phenotype due to loss of DNA mismatch repair mechanisms, which has large proportion in stage II of CRC.