For the lobe specific mediastinal lymph node, multivariate analysis of the 10 risk factors resulting from univariate analysis indicated that only the maximum diameter of the tumor (≤1.6 cm vs. > 1.6 cm, OR = 3.18, 95% CI 1.15–8.87; P = 0.026), position (P = 0.019), pulmonary membrane invasion (absent vs. present, OR = 4.60, 95% CI 1.60–13.23; P = 0.005), vascular invasion (absent vs. present, OR = 3.85, 95% CI 1.26–11.78; P = 0.018), and CEA (≤2.21 ng/mL vs. > 2.21 ng/mL, OR = 6.01, 95% CI 1.86–19.44; P = 0.003) were the 5 independent predictors associated with metastasis (Table 4). Here, CEACAM5 is linked to neoplasm.