Sex (male patients), maximum diameter of the tumor (> 1.6 cm), position (right lower lobe, right middle lobe, and ipsilateral mixed lobes), tumor differentiation, pulmonary membrane invasion, bronchial mucosa and cartilage invasion, vascular invasion, nerve invasion, CEA (> 2.21 ng/mL), and albumin (≤43.1 g/L) were the 10 significant risk factors associated with the presence of metastatic hilar lymph nodes. This evidence concerns the gene ALB and neoplasm.