For the pathway analysis, we adopted the KEGG category and found driver genes enrich in the Focal adhesion, Regulation of actin cytoskeleton, ErbB signaling pathway, MAPK signaling pathway, Non-small cell lung cancer, Chemokine signaling pathway, Calcium signaling pathway, Wnt signaling pathway etc. which are significant associated with lung cancer (see Additional file 2). Here, EGFR is linked to lung cancer.