CP and coinfection: Sfyroeras GS et al. revealed that [25] patients with CHD had a co-infection of CP with pathogenic microorganisms, such as Helicobacter pylori (Hp) and human cytomegalovirus (HCMV), and the long-term, repeated and chronic mixed infections of various pathogenic microorganisms could induce synergies between inflammatory markers, which jointly promote the occurrence and development of CHD.