NPPA and congestive heart failure: When examining the alterations in gene expression in RGZ‐treated CHF rats compared with those treated with Veh, two general observations are apparent: (a) RGZ treatment reduced the expression of ANP signalling‐related genes that are up‐regulated in untreated CHF rats; (b) several individual genes of various physiological functions were differentially regulated by RGZ treatment regardless of their altered expression in the CHF disease state.