NPPA and type 2 diabetes mellitus: In support of our findings, Trivedi et al and others suggest that TZD treatment improves ANP‐induced natriuresis in insulin‐resistant rodents and patients without CHF, probably via increased ANP secretion and/or second messenger generation.33, 34, 35 Several publications reported that a week‐long treatment with RGZ in T2DM patients without clinical cardiovascular disease improved the natriuretic response to water immersion‐induced volume expansion, which is known to be blunted in diabetes.