In addition, when inspecting the alterations in the NPR family genes (Figure 7), despite the general pattern of RGZ treatment in reducing back the expression of genes that were up‐regulated in CHF rats, the expression of NPR3 (coding for NPR‐C) in the renal medulla was up‐regulated about twofold (P < 0.05) independently of this pattern. Here, NPR3 is linked to congestive heart failure.