This improvement was accompanied by elevated plasma ANP levels and UcGMPV relative to untreated patients and was suggested to serve as an ‘escape’ mechanism from TZD‐induced fluid retention.36, 37, 38, 39 In our study, we also have found considerable improvements in the excretory responses to saline or ANP infusion in RGZ‐treated control rats, though to a lesser degree than in treated CHF rats. This evidence concerns the gene NPPA and congestive heart failure.