In support of our findings, Trivedi et al and others suggest that TZD treatment improves ANP‐induced natriuresis in insulin‐resistant rodents and patients without CHF, probably via increased ANP secretion and/or second messenger generation.33, 34, 35 Several publications reported that a week‐long treatment with RGZ in T2DM patients without clinical cardiovascular disease improved the natriuretic response to water immersion‐induced volume expansion, which is known to be blunted in diabetes. The gene discussed is NPPA; the disease is congestive heart failure.