ADAM10 and Alzheimer disease: Intriguingly, linkage disequilibrium between these two sites was observed via haplotype analysis, and compared to the A‐G haplotype (rs514049‐rs653765), the C‐A haplotype showed decreased levels of soluble APPα in AD but higher levels than those in healthy controls.57 This finding implies the differential involvement of TFs in ADAM10 transcriptional regulation.