A total of 143 genes were observed to be differentially expressed in transgenic mice compared with the wild‐type mice, with most genes being implicated in nervous system development, neuronal projections and synaptic transmission.37 The crucial role of ADAM10 in brain development has been repeatedly described in recent years, and cortical dysplasia is one of the most common aetiologies of intractable epilepsy, especially in early‐onset patients.38, 39, 40, 41 These previous results imply the involvement of ADAM10 in epilepsy via the modulation of cortical development. The gene discussed is ADAM10; the disease is cerebral cortical dysplasia.