Because of the competitive role of ADAM10 in inhibiting Aβ aggregation, the decreased function of this molecule seems to be a key factor for amyloidogenic processes.27, 28, 29, 30, 31 Thus, interest has increased into whether the Aβ burden mediated by ADAM10 is involved in epileptic seizures as well as in cognitive decline in AD. Here, ADAM10 is linked to Alzheimer disease.