These clusters successfully classified GAS strains into those that contain (a) a Pg/Pm direct binding M‐like protein, ‘PAM’ and usually induce invasive skin infections (SK2b), (b) a fibrinogen (Fg) binding M1 protein that does not directly interact with Pg and usually induce upper respiratory tracts (UTR) infections (SK2a) and (c) a M protein that does not interact with either Pg or Fg (SK1) and optimally activates Pg in solution. Here, JUP is linked to infection.