EZH2 and thyroid cancer: The dysregulation of EZH2 in tumour cells contributes to inhibitory roles of tumour suppressor genes, leading to the carcinogenesis.26 The miR‐124‐3p and miR‐506‐3p were reported as potential biomarker for the DTC.18, 19 In our study, we found that overexpression of miR‐124‐3p and miR‐506‐3p modulated the expression of EZH2 in sorafenib resistant thyroid cancer cells, leading to the regulation of H3K27me3 and H3K27Ac.