More specifically, Notch signalling can amplify the proinflammatory response of microglia by enhancing the NF‐κB p65 signalling.25 To clarify the molecular mechanism underlying FD‐induced neuroinflammation response in activated microglia, the protein expression of Notch1 was investigated in Iba‐1‐labelled cells in three hippocampus subregions 24 hours after ischaemia reperfusion. This evidence concerns the gene AIF1 and Fabry disease.