NFKB1 and infection: Dissociation from IκB and subsequent nuclear translocation of NF‐κB is initiated by the degradation of IκB through cytokine‐induced IkB kinase activation.26 Once activated, NF‐κB acts as an important transcription regulator for the expression of various genes involved in inflammation, infection and immune response including the genes for IL‐1β, TNF‐α and IL‐6.