Furthermore, recent studies have shown that Nurr1‐activating compounds, Nurr1 modulators, and Nurr1‐based cell transplantation have certain therapeutic effects on PD animal model.15, 24, 25, 26 However, most of these studies ignored the interference of the hostile and inflammatory environments, which could seriously damage the outcome of these treatments. The gene discussed is NR4A2; the disease is Parkinson disease.