DISC1 and schizophrenia: We focused on the core circuit underlying memory and executive abilities, the prelimbic–hippocampal network, and showed that shortly after birth, the early patterns of coordinated activity in PL and HP appear disorganized with lower power in mice modelling 22q11.2 microdeletions, a genetic variant highly penetrant for schizophrenia, and mice combining genetic dysfunction with an environmental stressor (DISC1 + MIA, Df16 + MIA).