Furthermore, it was shown that increased expression of NFAT4 in activated astrocytes was observed in hippocampus of a murine Alzheimer's disease model [31] and that amyloid β expression in hippocampus was suppressed by administration of tacrolimus or NFAT inhibitor in the murine Alzheimer's disease model [32]. Here, NFATC3 is linked to early-onset autosomal dominant Alzheimer disease.