ERBB2 and cancer: While trastuzumab showed a survival benefit as first-line chemotherapy for HER2+ G/GEJ cancer patients in the ToGA study, none of the other anti-HER2 drugs, such as lapatinib or trastuzumab–emtansine (T-DM1), or continuing trastuzumab beyond progression in second-line treatment showed benefits [8-10].