As the second-line treatment in a randomized phase 2 study conducted by the West Japan Oncology Group (WJOG7112G [T-ACT]), trastuzumab plus paclitaxel showed no benefit over paclitaxel alone in patients with HER2+ advanced G/GEJ cancer refractory to first-line trastuzumab plus chemotherapy [8]. The gene discussed is ERBB2; the disease is cancer.