SNHG14 and Prader-Willi syndrome: In the vast majority of cases of PWS, individuals have a genetic or epigenetic abnormality that leads to complete loss of all paternally expressed genes on 15q11–q13, including MKRN3, MAGEL2, NDN, NPAP1, SNURF-SNRPN, the C/D box small nucleolar (sno) RNAs SNORD109A, SNORD115 and SNORD116 (previously termed HBII-438A, HBII-52 and HBII-85, respectively) and the non-coding RNA IPW. However, rare clinical cases have narrowed the critical PWS genetic interval to a region spanning the SNORD116 repeat and the IPW gene (8–10).