VEGFA and ischemic disease: The molecular mechanisms of how endothelial cells (ECs) develop, proliferate, migrate, and adhere has been clarified [4, 5], and key molecules such as the vascular endothelial growth factor (VEGF), hepatocyte growth factor (HGF), or basic fibroblast growth factor (bFGF) have been used in clinical applications for ischemic diseases [6–8].