CASR and colorectal carcinoma: Most of the published articles revealed that CASR expression play a protective role in CRC patients through several mechanisms such as binding toxic secondary bile acids and/or ionized fatty acids and neutralizing them in form of insoluble calcium soaps,10 or by affecting several signaling transductions such as stimulating cell differentiation, inducing apoptosis and inhibiting proliferation.11 To the best of our knowledge, no studies have been conducted to correlate the relation between genetic polymorphisms in CASR gene and risk of CRC in Saudi patients.