Around one hundred and twelve mutations (98 missense, 6 nonsense, 8 insertion and/or deletion, and one splice mutation) have been described in the CASR mutation database and were tested for their contributions to several diseases including diabetes mellitus, kidney diseases, and parathyroid adenoma.12,21,22 However, fewer researches were conducted on CRC patients. The gene discussed is CASR; the disease is parathyroid gland adenoma.