Around one hundred and twelve mutations (98 missense, 6 nonsense, 8 insertion and/or deletion, and one splice mutation) have been described in the CASR mutation database and were tested for their contributions to several diseases including diabetes mellitus, kidney diseases, and parathyroid adenoma.12,21,22 However, fewer researches were conducted on CRC patients. Here, CASR is linked to colorectal carcinoma.