However on the contrary there were few studies which revealed that although sitagliptin significantly improved hemodynamic and metabolic parameters in Tyupe-2 diabetic patients but failed to improved inflammation marked by reduction of CRP.18-20 The probable reason in these studies was that some of the patients have already concurrent illness such as dyslipidemia, obesity, hypertension and coronary artery disease. The gene discussed is CRP; the disease is hypertensive disorder.