Although, the underlying mechanisms of the aging process are not fully understood.1 Aging is associated with inflammation and biomarkers such as IL-6.13 Aging process might be a factor in development and progress of anemia with dysregulation of some proinflammatory cytokines.3 These studies about changes of antimicrobial proteins throughout Aging and in iron deficiency are not sufficient. This evidence concerns the gene IL6 and anemia (phenotype).